The 2025 British Society for Rheumatology management recommendations for ANCA-associated vasculitis
Kathryn Biddle, Judith Jade, Harold Wilson-Morkeh, Madura Adikari, Chadwan Al Yaghchi, Zoi Anastasa, Neil Basu, Paul Brogan, Dimitrios Chanouzas, Shouvik Dass, David D’Cruz, Marcos Martinez Del Pero, Emmandeep Dhillon, Georgina Ducker, Siân Griffin, Rosemary Hollick, David J. Jackson, Catherine King, Matko Marlais, Alice Mason, Stephen P. McAdoo, Devesh Mewar, Janice Mooney, Eleana Ntatsaki, Fiona Pearce, Benjamin Rhodes, Hitasha Rupani, Alan D. Salama, Salman Siddiqui, Rona Smith, Lorraine Harper, British Society for Rheumatology Guideline Steering Group, Christopher Joyce, Zoe McLaren, Claire Jones, Karen Merrison, Edward Roddy, Pratyasha Saha, Emma Williams, Emily Rose‐Parfitt, Devesh Mewar, Caroline Cotton, Sandrine Compeyrot-Lacassagne, Anoop Kuttikat, Hirushi Jayasekera, Coziana Ciurtin
Abstract
ANCA-associated vasculitis (AAV) is comprised of three specific conditions: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Since the publication of the last British Society for Rheumatology (BSR) and British Health Professionals in Rheumatology (BHPR) guideline for the management of adults with AAV in 2014, a plethora of randomized controlled trials, additional research and recommendations have provided novel insights into how the management of AAV can be optimized, thus improving patient quality of life. The BSR AAV Working Group (WG) reviewed published guidelines, undertook a systematic literature review and utilized expertise from specialist vasculitis centres across the UK and patient representatives to formulate a list of 26 recommendations with corresponding strength of agreement (SOA) scores. Recommendations were updated from the published 2014 BSR and BHPR guideline. The 26 recommendations encompassed five key domains: 1. Treatment for GPA and MPA; 2. Management of subglottic stenosis and ear, nose and throat (ENT) manifestations of AAV; 3. Management and treatment for EGPA; 4. Service specifications; 5. Patient education and support. These recommendations provide an update on care delivery of AAV based on current evidence and specialist opinion. In addition, we have provided research and audit recommendations to support equitable access to care and improve health outcomes. The lay summary that accompanies this abstract can be found in Supplementary Data S1, available at Rheumatology online.