Novel fluorophenyl tethered thiazole and chalcone analogues as potential anti-tubercular agents: Design, synthesis, biological and in silico evaluations
Babita Kushwaha, Narva Deshwar Kushwaha, M. Hamsa Priya, Balakumar Chandrasekaran, Vincent A. Obakachi, Ruchika Chauhan, Saqib Kidwai, Ramandeep Singh, Ab Majeed Ganai, Rajshekhar Karpoormath
Topics & Concepts
ChemistryIn silicoChalconeDNA gyraseADMEAntimycobacterialThiazoleLipinski's rule of fiveCombinatorial chemistryStereochemistryVirtual screeningMycobacterium tuberculosisMolecular modelLead compoundIn vitroBiochemistryPharmacophoreTuberculosisEscherichia coliGenePathologyMedicineSynthesis and biological activityCancer therapeutics and mechanismsSynthesis and Biological Evaluation