Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents
Abdelmoula El Abbouchi, Nabil El Brahmi, Marie‐Aude Hiebel, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saı̈d El Kazzouli
Topics & Concepts
ChemistryPiperazineHL60Cell cultureA549 cellLinkerAcetic acidIn vitroCombinatorial chemistryCancer cell linesCancer cellCytotoxicityIC50StereochemistryCancerBiochemistryOrganic chemistryOperating systemMedicineGeneticsComputer scienceInternal medicineBiologyEnzyme function and inhibitionCancer therapeutics and mechanismsHIV/AIDS drug development and treatment