Amphiphilic mannose-6-phosphate glycopolypeptide-based bioactive and responsive self-assembled nanostructures for controlled and targeted lysosomal cargo delivery
Basudeb Mondal, Bhawana Pandey, Nimisha Parekh, Sidharth Panda, Tahiti Dutta, Abinash Padhy, Sayam Sen Gupta
Abstract
M6P-receptors are overexpressed in specific cancer cells (such as breast cancer) and are also involved in the trafficking of mannose-6-phosphate labeled proteins exclusively onto lysosomes<italic>via</italic>cell surface M6P receptor (CI-MPR) mediated endocytosis.
Topics & Concepts
Mannose 6-phosphateEndocytosisMannoseLysosomeMannose receptorChemistryReceptorCancer cellCell biologyReceptor-mediated endocytosisGlycoproteinAmphiphileBiochemistryCancerBiologyCopolymerEnzymeGrowth factorPolymerOrganic chemistryMacrophageIn vitroGeneticsSupramolecular Self-Assembly in MaterialsAdvanced biosensing and bioanalysis techniquesLipid Membrane Structure and Behavior