Rh-Catalyzed [4 + 2] Annulation with a Removable Monodentate Structure toward Iminopyranes and Pyranones by C–H Annulation
Leiqing Fu, Wenqiang Xu, Maoping Pu, Yun‐Dong Wu, Yunyun Liu, Jie‐Ping Wan
Abstract
-pyridinyl enaminones with internal alkynes leading to the synthesis of iminopyranes via a key C-H bond activation and subsequent tautomeric O-H bond cleavage are reported. Moreover, the pyridine ring in the amino group acts as an auxiliary monodentate site for this annulation and can be easily removed by a simple hydrolysis to afford pyranones.
Topics & Concepts
AnnulationChemistryTautomerDenticityCatalysisPyridineHydrolysisMedicinal chemistryCleavage (geology)Bond cleavageStereochemistryOrganic chemistryCrystal structureGeotechnical engineeringEngineeringFracture (geology)Catalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms