Structural Basis of Metallo-β-lactamase Inhibition by<i>N</i>-Sulfamoylpyrrole-2-carboxylates
Alistair J. M. Farley, Yuri Ermolovich, Karina Calvopiña, Patrick Rabe, Tharindi Panduwawala, Jürgen Brem, Fredrik Björkling, Christopher J. Schofield
Abstract
NDM-1. The results support the potential of NSPCs and related compounds as efficient MBL inhibitors, though further optimization is required for their clinical development.
Topics & Concepts
Clavulanic acidSerineDocking (animal)Beta-Lactamase InhibitorsStereochemistryAntibioticsChemistrySubclassBiochemistryCombinatorial chemistryMicrobiologyBiologyEnzymeAmoxicillinMedicineNursingImmunologyAntibodyAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatmentPhenothiazines and Benzothiazines Synthesis and Activities