Novel indolyl 1,2,4-triazole derivatives as potential anti-proliferative agents: <i>in silico</i> studies, synthesis, and biological evaluation
Sarah A. Ghobish, Khaled O. Mohamed, Nahla A. Farag, Doaa Boshra Farag
Abstract
phase. The binding mode and interactions of all compounds were studied and found to mimic those of the FDA approved CDK4/6 inhibitor palbociclib that was used as a reference throughout the study.
Topics & Concepts
StaurosporineChemistryCell cycleCytotoxicityCyclin-dependent kinase 6IC50StereochemistryApoptosisKinasePharmacologyCyclin-dependent kinase 2BiochemistryIn vitroBiologyProtein kinase CAdvanced Breast Cancer TherapiesClick Chemistry and ApplicationsLung Cancer Research Studies