Subinhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by Upregulating <i>cidA</i>
Ye Jin, Yinjuan Guo, Qing Zhan, Yongpeng Shang, Di Qu, Fangyou Yu
Abstract
Previous studies have shown that the administration of antibiotics at subinhibitory concentrations stimulates biofilm formation by the majority of multidrug-resistant Staphylococcus aureus (MRSA) strains. Here, we investigated the effect of subinhibitory concentrations of mupirocin on biofilm formation by the community-associated (CA) mupirocin-sensitive MRSA strain USA300 and the highly mupirocin-resistant clinical S. aureus SA01 to SA05 isolates.
Topics & Concepts
MupirocinStaphylococcus aureusMicrobiologyBiofilmAntibioticsMicrococcaceaeStaphylococcal infectionsDaptomycinMultidrug toleranceBiologyMethicillin-resistant Staphylococcus aureusAntibacterial agentChemistryBacteriaVancomycinGeneticsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingAntimicrobial Peptides and Activities