Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives
Yi Liu, Puying Luo, Yang Fu, Tianxin Hao, Xuan Liu, Qiuping Ding, Yiyuan Peng
Abstract
Great progress has been made in the tandem annulation of enynes in the past few years. This review only presents the corresponding reactions of 1,3-enyne structural motifs to provide the functionalized pyridine and pyrrole derivatives. The functionalization reactions cover iodination, bromination, trifluoromethylation, azidation, carbonylation, arylation, alkylation, selenylation, sulfenylation, amidation, esterification, and hydroxylation. We also briefly introduce the applications of the products and the reaction mechanisms for the synthesis of corresponding N-heterocycles.
Topics & Concepts
AnnulationChemistryTandemPyridineHalogenationCombinatorial chemistryPyrroleAlkylationTrifluoromethylationOrganic chemistryCatalysisTrifluoromethylAlkylMaterials scienceComposite materialSynthesis and Characterization of PyrrolesCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques