<i>In vitro</i>biological evaluation of epigallocatechin gallate (EGCG) release from three-dimensional printed (3DP) calcium phosphate bone scaffolds
Yongdeok Jo, Naboneeta Sarkar, Susmita Bose
Abstract
release kinetics study demonstrates that EGCG shows a ∼64% release within a day followed by a sustained release in the physiological environment (pH 7.4) because its phenolic hydroxyl groups are easily deprotonated at physiological pH. These findings contribute to developing a multifunctional scaffold for the treatment of low load-bearing patient-specific bone defects after trauma and tumor excision.
Topics & Concepts
Epigallocatechin gallateIn vitroGallateMaterials scienceScaffoldCalciumBiomedical engineeringCalcium phosphate cementChemistryBiochemistryNuclear chemistryPolyphenolMedicineMetallurgyAntioxidantBone Tissue Engineering MaterialsDental Implant Techniques and OutcomesDental materials and restorations