Design, synthesis, pharmacological and in silico screening of disubstituted-piperazine derivatives as selective and reversible MAO-A inhibitors for treatment of depression
Nilay Kumar Nandi, Rohit Bhatia, Suresh Saini, Ravi Rawat, Shilpa Sharma, Khadga Raj, Naresh Kumar Rangra, Bhupinder Kumar
Topics & Concepts
ChemistryPiperazineMonoamine oxidaseIn vivoBehavioural despair testAnimal models of depressionTail suspension testMonoamine oxidase BMoclobemideDPPHIC50StereochemistryIn silicoAntidepressantIn vitroPharmacologyEnzymeBiochemistryOrganic chemistryAntioxidantNeuroscienceGeneBiotechnologyHippocampusBiologyMedicineCholinesterase and Neurodegenerative DiseasesTreatment of Major DepressionChemical synthesis and alkaloids