Primordial non-responsiveness: a neglected obstacle to cardioprotection
Gerd Heusch, Hans Erik Bøtker, Péter Ferdinandy, Rainer Schulz
Abstract
Schematic diagram listing the established confounders of cardioprotection and characterizing in more detail the features of the novel confounder ‘primordial non-responsiveness to cardioprotection’, as evidenced by lack of protection (reduced arrhythmias, contractile dysfunction, infarct size, and coronary microvascular obstruction) from ischaemic conditioning interventions in rat and pig strains.
Topics & Concepts
CardioprotectionMedicineConfoundingCardiologySchematicInternal medicineMyocardial infarctionEngineeringElectronic engineeringCardiac Ischemia and ReperfusionCardiac Arrest and ResuscitationAnesthesia and Neurotoxicity Research