Measuring neuronal activity with diffuse correlation spectroscopy: a theoretical investigation
Xiaojun Cheng, Edbert J. Sie, Stephanie Naufel, David A. Boas, Francesco Marsili
Abstract
Significance: Diffuse correlation spectroscopy (DCS) measures cerebral blood flow noninvasively. Variations in blood flow can be used to detect neuronal activities, but its peak has a latency of a few seconds, which is slow for real-time monitoring. Neuronal cells also deform during activation, which, in principle, can be utilized to detect neuronal activity on fast timescales (within 100 ms) using DCS.
Topics & Concepts
Premovement neuronal activitySpeckle patternSIGNAL (programming language)Latency (audio)AutocorrelationBlood flowComputer scienceNeuroscienceBiological systemArtificial intelligenceBiologyMedicineMathematicsTelecommunicationsStatisticsProgramming languageInternal medicineOptical Imaging and Spectroscopy TechniquesPhotoacoustic and Ultrasonic ImagingHemodynamic Monitoring and Therapy