pH Stimuli‐Responsive, Rapidly Self‐healable Coatings Enhanced the Corrosion Resistance and Osteogenic Differentiation of Mg‐1Ca Osteoimplant
Dandan Xia, Zhaojun Jia, Yunong Shen, Yufeng Zheng, Yan Cheng, Pan Xiong, Shaokang Guan, Yuqian Xu, Fan Yang, Yunsong Liu, Yongsheng Zhou
Abstract
Mg-Ca alloys have emerged as a promising research direction for biomedical implants in the orthopedic field. However, their clinical use is deterred by their fast corrosion rate. In this work, a pH stimuli-responsive silk-halloysite (HNT)/phytic acid (PA) self-healing coating (Silk-HNT/PA) is constructed to slow down the corrosion rate of Mg-1Ca alloy and its cell viability and osteogenic differentiation ability are enhanced. The Silk-HNT/PA coating exhibits appealing active corrosion protection, by eliciting pH-triggerable self-healing effects, while simultaneously affording superior biocompatibility and osteogenic differentiation ability. Moreover, in vivo studies by histological analysis also demonstrate better osseointegration for the Silk-HNT/PA coated Mg-1Ca alloy. In summary, the Silk-HNT/PA coating in the present study has great potential in enhancing the biomedical utility of Mg alloys.