Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer
Huiming Zhang, Zhicheng Ge, Zihan Wang, Yinguang Gao, Yang Wang, Xiang Qu
Abstract
. In conclusion, we discovered that circRHOT1 contributed to malignant progression and attenuated ferroptosis in breast cancer by the miR-106a-5p/STAT3 axis. Our finding provides new insights into the mechanism by which circRHOT1 promotes the development of breast cancer. CircRHOT1 and miR-106a-5p may serve as potential targets for breast cancer therapy.
Topics & Concepts
Breast cancerCircular RNAmicroRNARNACancer researchCancerMedicineBiologyInternal medicineGeneGeneticsCircular RNAs in diseasesCancer-related molecular mechanisms researchFerroptosis and cancer prognosis