Facile Approach to Prepare rGO@Fe3O4 Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
Chunyong Liang, Ji‐Ying Song, Yongguang Zhang, Yaping Guo, Meigui Deng, Wei Gao, Jimin Zhang
Abstract
Abstract Near-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of Fe 3 O 4 -decorated hollow graphene microspheres (rGO@Fe 3 O 4 ) by a facile spray drying and coprecipitation method for the magnetically targeted and NIR-responsive chemo-photothermal combination therapy. The microspheres displayed very high specific surface area (~ 120.7 m 2 g −1 ) and large pore volume (~ 1.012 cm 3 g −1 ), demonstrating distinct advantages for a high loading capacity of DOX (~ 18.43%). NIR triggered photothermal effect of the rGO@Fe 3 O 4 microspheres responded in an on-off manner and induced a high photothermal conversion efficiency. Moreover, The Fe 3 O 4 on the microspheres exhibited an excellent tumor cells targeting ability. The chemo-photothermal treatment based on rGO@Fe 3 O 4 /DOX showed superior cytotoxicity towards Hela cells in vitro. Our studies indicated that rGO@Fe 3 O 4 /DOX microcapsules have great potential in combined chemo-photothermal cancer treatment.