Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure
Josef Jansa, Radek Jorda, Jana Škerlová, Petr Pachl, Miroslav Peřina, Eva Řezníčková, Tomáš Heger, Tomáš Gucký, Pavlína Řezáčová, Antonı́n Lyčka, Vladimı́r Kryštof
Topics & Concepts
ChemistryCyclin-dependent kinase 2Isothermal titration calorimetryCyclin-dependent kinaseStereochemistryKinaseLead compoundCytotoxicityCombinatorial chemistryBiochemistryCell cycleProtein kinase ACellIn vitroSynthesis and Reactivity of HeterocyclesAdvanced Breast Cancer TherapiesCancer-related Molecular Pathways