Smoking History and Clinical Features of Cluster Headache: Results from the Korean Cluster Headache Registry
Pil‐Wook Chung, Byung‐Su Kim, Jeong‐Wook Park, Jong‐Hee Sohn, Mi Ji Lee, Byung‐Kun Kim, Min Kyung Chu, Jin Young Ahn, Yun-Ju Choi, Tae‐Jin Song, Dae Woong Bae, Daeyoung Kim, Jae-Moon Kim, Soo Kyoung Kim, Kwang‐Yeol Park, Jae Myun Chung, Heui‐Soo Moon, Kyungmi Oh, Chin‐Sang Chung, Soo‐Jin Cho
Abstract
BACKGROUND AND PURPOSE: Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry. METHODS: Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. We compared clinical and demographic features between ever-smokers (current or former smokers) and never-smokers. RESULTS: =0.001) were higher in never-smokers, while other clinical features such as pain severity, duration, attack frequency, and associated autonomic symptoms did not differ significantly between the groups. The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1). CONCLUSIONS: Most of the clinical features did not differ significantly between patients with a smoking history and never-smokers. However, the age at CH onset, sex ratio, and seasonal rhythmicity were significantly associated with smoking history.