Yeast β-glucan reduces obesity-associated <i>Bilophila</i> abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models
Sik Yu So, Qinglong Wu, Kin Sum Leung, Zuzanna Maria Kundi, Tor Savidge, Hani El‐Nezami
Abstract
The study shows that dietary Y-BG supplementation modulated gut microbiota, bile acid metabolism and associated signaling pathways. Y-BG significantly reduced Bilophila abundance which is associated with obesity in human cohorts. Correlation analysis confirmed functional interactions between bile acid composition, gut microbiota, and metabolic phenotype, although clinical benefit did not reach significance in an aggressive obesity model. Gut microbiota and bile acids correlated with metabolic parameters, indicating future potential of dietary Y-BG modulation of metabolic pathways.
Topics & Concepts
Gut floraPrebioticBile acidFood scienceChemistryBiochemistryObesityBiologyEndocrinologyGut microbiota and healthGastrointestinal motility and disordersCannabis and Cannabinoid Research