Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO
Fan Zhang, Mehdi Pirooznia, Hong Xu
Abstract
Deficiencies in electron transport chain complexes increase the activity of FOXO transcription factor in Drosophila midgut stem cells, which impairs stem cell proliferation and enterocyte specification.
Topics & Concepts
BiologyEnterocyteStem cellCell biologyTranscription factorMidgutHomeostasisMitochondrionStem cell factorCell growthCellGeneBiochemistrySmall intestineHaematopoiesisLarvaBotanyGenetics, Aging, and Longevity in Model OrganismsInvertebrate Immune Response MechanismsCRISPR and Genetic Engineering