Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
Paolo P. Provenzano, Carlos Cuevas, Amy Chang, Vikas Goel, Daniel D. Von Hoff, Sunil R. Hingorani
Topics & Concepts
StromaGemcitabineStromal cellCancer researchInterstitial fluidHyaluronic acidPancreatic cancerTumor microenvironmentPerfusionChemistryPancreatic ductal adenocarcinomaBiologyPathologyMedicineInternal medicineCancerTumor cellsImmunohistochemistryAnatomyPancreatic and Hepatic Oncology ResearchProteoglycans and glycosaminoglycans researchFibroblast Growth Factor Research