Discovery of novel nitrofuran PROTAC-like compounds as dual inhibitors and degraders targeting STING
Liang Xue, Ruixue Liu, Lican Zhang, Tingting Qiu, Lu Liu, Ruijuan Yin, Tao Jiang
Topics & Concepts
StingChemistryNitrofuranSmall moleculeDrugInnate immune systemPharmacologyCombinatorial chemistryBiochemistryReceptorMedicineEngineeringGeneticsAerospace engineeringBiologyinterferon and immune responsesUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors