FAdV-4 without <i>Fiber-2</i> Is a Highly Attenuated and Protective Vaccine Candidate
Quan Xie, Weikang Wang, Qiuqi Kan, Yaru Mu, Wei Zhang, Jian Chen, Luyuan Li, Hui Fu, Tuofan Li, Zhimin Wan, Wei Gao, Hongxia Shao, Aijian Qin, Jianqiang Ye
Abstract
Among all serotypes of fowl adenovirus, serotypes FAdV-1, FAdV-4, and FAdV-10 are unique members with two fiber genes ( fiber-1 and fiber-2 ). Recent studies reveal that Fiber-1, not Fiber-2, directly triggers viral infection of FAdV-4, whereas Fiber-2, but not Fiber-1, has been identified as the major virulence determiner and an efficient protective immunogen for subunit vaccines.
Topics & Concepts
VirologyBiologyRecombinant DNAFiberGeneGeneticsChemistryOrganic chemistryVirus-based gene therapy researchViral gastroenteritis research and epidemiologyViral Infectious Diseases and Gene Expression in Insects