<i>De novo</i> glycan sequencing by electronic excitation dissociation MS <sup>2</sup> -guided MS <sup>3</sup> analysis on an Omnitrap-Orbitrap hybrid instrument
Juan Wei, Dimitris Papanastasiou, Mariangela Kosmopoulou, Athanasios Smyrnakis, Pengyu Hong, Nafisa Tursumamat, Joshua Klein, Chaoshuang Xia, Yang Tang, Joseph Zaia, Catherine E. Costello, Cheng Lin
Abstract
EED MS 2 spectra were used to generate candidate topologies and guide selection of fragment(s) for MS 3 analysis. Isotoplogies indistinguishable at the MS 2 level may be differentiated by CID-EED MS 3 analysis.
Topics & Concepts
OrbitrapChemistryMass spectrometryDissociation (chemistry)GlycanAnalytical Chemistry (journal)ChromatographyPhysical chemistryBiochemistryGlycoproteinMass Spectrometry Techniques and ApplicationsGlycosylation and Glycoproteins ResearchGenomics and Phylogenetic Studies