New trends in cellular therapy
Hideyuki Okano, Douglas Sipp
Abstract
Regenerative therapies, including both gene and cellular therapies, aim to induce regeneration of cells, tissues and organs and restore their functions. In this short Spotlight, we summarize the latest advances in cellular therapies using pluripotent stem cells (PSCs), highlighting the current status of clinical trials using induced (i)PSC-derived cells. We also discuss the different cellular products that might be used in clinical studies, and consider safety issues and other challenges in iPSC-based cell therapy.
Topics & Concepts
BiologyInduced pluripotent stem cellCell therapyRegeneration (biology)Regenerative medicineClinical trialGenetic enhancementBioinformaticsStem cellComputational biologyNeuroscienceCell biologyGeneEmbryonic stem cellGeneticsPluripotent Stem Cells ResearchCRISPR and Genetic EngineeringPancreatic function and diabetes