Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45
Natalie Effelsberg, Marc Stegger, Lena Peitzmann, Ozan Altınok, Geoffrey W. Coombs, Bruno Pichon, Angela Kearns, Pranay R. Randad, Christopher D. Heaney, Stefan Bletz, Frieder Schaumburg, Alexander Mellmann
Abstract
Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries. De novo -assembled genomes were used to understand genomic plasticity and to perform coalescent analyses.
Topics & Concepts
Staphylococcus aureusEpidemiologyStaphylococcal infectionsBiologyMicrobiologyMedicineBacteriaGeneticsPathologyAntimicrobial Resistance in StaphylococcusMicrobial Metabolism and ApplicationsBacterial biofilms and quorum sensing