A validation study of UCSD-Mayo risk score in predicting hospital-acquired acute kidney injury in COVID-19 patients
Zhengying Fang, Chenni Gao, Yikai Cai, Lin Lu, Haijin Yu, Hafiz Muhammad Jafar Hussain, Zijin Chen, Chuanlei Li, Wenjie Wei, Yuhan Huang, Xiang Li, Shuwen Yu, Yinhong Ji, Qinjie Weng, Yan Ouyang, Xiaofan Hu, Jun Tong, Jian Liu, Jian Liu, Mingyu Liu, Xiaoman Xu, Yixin Zha, Zhiyin Ye, Tingting Jiang, Jieshuang Jia, Jialin Liu, Jialin Liu, Yufang Bi, Nan Chen, Weiguo Hu, Huiming Wang, Jun Liu, Jun Liu, Jingyuan Xie
Abstract
INTRODUCTION: Acute kidney injury (AKI) in coronavirus disease 2019 (COVID-19) patients is associated with poor prognosis. Early prediction and intervention of AKI are vital for improving clinical outcome of COVID-19 patients. As lack of tools for early AKI detection in COVID-19 patients, this study aimed to validate the USCD-Mayo risk score in predicting hospital-acquired AKI in an extended multi-center COVID-19 cohort. METHODS: Five hundred seventy-two COVID-19 patients from Wuhan Tongji Hospital Guanggu Branch, Wuhan Leishenshan Hospital, and Wuhan No. Ninth Hospital was enrolled for this study. Patients who developed AKI or reached an outcome of recovery or death during the study period were included. Predictors were evaluated according to data extracted from medical records. RESULTS: = 0.32) and calibration in our cohort. Further analysis showed that the UCSD-Mayo risk score performed well in subgroups defined by gender, age, and several chronic comorbidities. However, the discrimination of the UCSD-Mayo risk score in ICU patients and patients with mechanical ventilation was not good which might be resulted from different risk factors of these patients. CONCLUSIONS: We validated the performance of UCSD-Mayo risk score in predicting hospital-acquired AKI in COVID-19 patients was excellent except for patients from ICU or patients with mechanical ventilation.