Mechanism and reversal of drug-induced nephrotoxicity on a chip
Aarón Cohen, Konstantinos Ioannidis, Avner Ehrlich, Shaun Regenbaum, Merav Cohen, Muneef Ayyash, Sigal Shafran Tikva, Yaakov Nahmias
Abstract
< 0.001) improvement of kidney function, as well as reduction in creatinine and uric acid, markers of kidney damage. These results demonstrate the potential of sensor-integrated kidney-on-chip platforms to elucidate mechanisms of action and rapidly reformulate effective therapeutic solutions, increasing drug safety and reducing the cost of clinical and commercial failures.
Topics & Concepts
NephrotoxicityEmpagliflozinPharmacologyLipotoxicityRenal glucose reabsorptionKidneyToxicityRenal functionChemistryDrugPopulationReabsorptionRenal physiologyCisplatinMedicineEndocrinologyInternal medicineDiabetes mellitusChemotherapyType 2 Diabetes MellitusInsulin resistanceEnvironmental healthChemotherapy-induced organ toxicity mitigationRenal Transplantation Outcomes and TreatmentsPharmacological Effects and Toxicity Studies