κ-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling
Jin Niu, Chen Wu, Min Zhang, Zhen Yang, Zhenhua Liu, Feng Fu, Jun Li, Na Feng, Xiaoming Gu, Shumiao Zhang, Yali Liu, Rong Fan, Juan Li, Jianming Pei
Abstract
. Collectively, our experiments show that κ-opioid receptor activation inhibits VSMC calcification by reducing PFKFB3 expression and lactate content, providing a potential drug target and strategy for the clinical treatment of vascular calcification.
Topics & Concepts
Vascular smooth muscleCalcificationChemistryInternal medicineEndocrinologyReceptorAgonistBiologyBiochemistryMedicineSmooth muscleParathyroid Disorders and TreatmentsCaveolin-1 and cellular processesVitamin K Research Studies