Three new cadinane-type sesquiterpenes from <i>Eupatorium adenophorum</i> spreng.
Xu Liang, Xinzhou Yang, Tongxi Zhou, Yuanren Ma, Peng Yu, Yeerlan Bahetejiang, Yuzhao Li, Jing‐Quan Yuan
Abstract
Three new cadinane-type sesquiterpenes, eupatorinones A-C (1-3), along with seven known compounds (4-10), were obtained from the petroleum ether fraction of 95% ethanol extract of Eupatorium adenophorum Spreng. The structures of these new compounds were determined by NMR, MS, and ECD spectra analysis. The configuration of compound 3 was established by quantum chemical calculations of NMR chemical shifts and ECD spectra, that matched the experimental data. In addition, compounds 1, 3 and 5 increased the glucose uptake in L6 cells by 1.42, 1.21 and 1.60 times, respectively.
Topics & Concepts
EupatoriumPetroleum etherChemical shiftChemical constituentsChemistryEtherOrganic chemistryStereochemistryBotanyQuantum chemicalEthanolFraction (chemistry)BiologyExtraction (chemistry)ChromatographyMoleculePhysical chemistryNatural product bioactivities and synthesisSesquiterpenes and Asteraceae StudiesPlant Toxicity and Pharmacological Properties