Ploidy dynamics increase the risk of liver cancer initiation
Miryam Müller, Stephanie May, Thomas G. Bird
Abstract
Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.
Topics & Concepts
PloidyCancerLiver cancerDiseaseLiver diseaseCancer researchBiologyDynamics (music)MedicineBioinformaticsImmunologyGeneticsPathologyInternal medicinePsychologyGenePedagogyMicrotubule and mitosis dynamicsLipid metabolism and biosynthesisEvolution and Genetic Dynamics