Emergence of Carbapenem-Resistant Providencia rettgeri and <i>Providencia stuartii</i> Producing IMP-Type Metallo-β-Lactamase in Japan
Shu Iwata, Tatsuya Tada, Tomomi Hishinuma, Mari Tohya, Satoshi Oshiro, Kyoko Kuwahara‐Arai, Miho Ogawa, Masahiro Shimojima, Teruo Kirikae
Abstract
Four Providencia rettgeri isolates and one Providencia stuartii isolate were obtained from urine samples of five patients in 2018 in Japan. All of the isolates were resistant to imipenem and meropenem, and three were highly resistant to both carbapenems, with MICs of 512 μg/ml. The three highly carbapenem-resistant isolates harbored bla IMP-70 , encoding a variant of IMP-1 metallo-β-lactamase with two amino acid substitutions (Val67Phe and Phe87Val), and the other two harbored bla IMP-1 and bla IMP-11 , respectively.
Topics & Concepts
ProvidenciaBiologyImipenemMeropenemMicrobiologyCarbapenemPlasmidEnterobacteriaceaeEscherichia coliGeneGeneticsAntibiotic resistanceAntibioticsAntibiotic Resistance in BacteriaInfections and bacterial resistanceBacterial biofilms and quorum sensing