Ruthenium catalyzed β-selective alkylation of vinylpyridines with aldehydes/ketones<i>via</i>N<sub>2</sub>H<sub>4</sub>mediated deoxygenative couplings
Leiyang Lv, Chao‐Jun Li
Abstract
mediated deoxygenative couplings. Compared with one-electron umpolung of carbonyls to alcohols, this two-electron umpolung strategy realized reductive deoxygenation targets, which were not only applicable to the regioselective alkylation of a broad range of 2/4-alkene substituted pyridines, but also amenable to challenging 3-vinyl and steric-embedded internal pyridines as well as their analogous heterocyclic structures.
Topics & Concepts
UmpolungAlkylationChemistryRegioselectivityElectrophileAldehydeDeoxygenationRutheniumAlkeneCatalysisSteric effectsOrganic chemistryReagentReactivity (psychology)Combinatorial chemistryMedicinal chemistryNucleophilePathologyMedicineAlternative medicineCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry Methods