A conformational tweak for enhanced cellular internalization, photobleaching resistance and prolonged imaging efficacy
Niranjan Meher, Anil P. Bidkar, Debasish Barman, Siddhartha Sankar Ghosh, Parameswar Krishnan Iyer
Abstract
A strategy of conformational tweaking regulates the condensed state behavior of naphthalimide skeletal isomers (NSIs) and enhances their photophysical properties, cellular uptake and prolonged imaging capability. This salient approach results in a large Stokes shift (>120 nm), rapid cellular internalization, photobleaching resistance, and efficient bioimaging of the ribbon-like nano-assembly superior to that of its electronically similar micro-flower isomer.
Topics & Concepts
InternalizationPhotobleachingBiophysicsChemistryCell biologyNanotechnologyMaterials scienceBiochemistryBiologyFluorescenceReceptorQuantum mechanicsPhysicsLuminescence and Fluorescent MaterialsSupramolecular Self-Assembly in MaterialsPolydiacetylene-based materials and applications