Photoredox/Copper Dual-Catalyzed Regioselective 1,4-Arylcyanation of 1,3-Enynes for Multifunctionalized Allenyl Nitriles
Qilong Wu, Xufeng Li, Jian Lv, Yongjia Shi, Daoshan Yang
Abstract
A copper/photoredox dual-catalysis-enabled 1,4-arylcyanation of 1,3-enynes to afford tetrasubstituted allenyl nitriles was initially developed. The reaction features good reaction generality and high reaction regioselectivity, providing facile access to multifunctionalized allenyl nitriles. This strategy achieves the construction of aryl-containing tetrasubstituted allenyl nitriles via indirect arene C-H functionalization. It also serves as an important complement to thianthrenium salt chemistry.
Topics & Concepts
RegioselectivityChemistryCatalysisCopperDual (grammatical number)Combinatorial chemistryDual roleOrganic chemistryLiteratureArtCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques