Mechanism of fibroblast growth factor 21 in cardiac remodeling
Zeyu Zhao, Xuemei Cui, Zhangping Liao
Abstract
Cardiac remodeling is a basic pathological process that enables the progression of multiple cardiac diseases to heart failure. Fibroblast growth factor 21 is considered a regulator in maintaining energy homeostasis and shows a positive role in preventing damage caused by cardiac diseases. This review mainly summarizes the effects and related mechanisms of fibroblast growth factor 21 on pathological processes associated with cardiac remodeling, based on a variety of cells of myocardial tissue. The possibility of Fibroblast growth factor 21 as a promising treatment for the cardiac remodeling process will also be discussed.
Topics & Concepts
Heart failurePathologicalFibroblastFibroblast growth factorMedicineVentricular remodelingRegulatorMechanism (biology)Growth factorCardiac fibrosisCancer researchCell biologyInternal medicineBiologyGeneticsGeneIn vitroReceptorPhilosophyEpistemologyPeptidase Inhibition and AnalysisCardiac Fibrosis and RemodelingCardiac Structural Anomalies and Repair