Straightforward Synthesis of Fluorinated Enals <i>via</i> Photocatalytic α-Perfluoroalkenylation of Aldehydes
Christian Wulkesch, Constantin Czekelius
Abstract
(Per)fluorinated substances represent an important compound class with regard to drug design and material chemistry. We found a mild, operationally simple, and inexpensive photocatalytic perfluoroalkenylation reaction giving tetrasubstituted, highly electron-deficient enals straight from aldehydes. This one-step reaction tolerates various functional groups and can be applied to a wide range of substrates giving the products in yields of 52-84%.
Topics & Concepts
ChemistryPhotocatalysisCombinatorial chemistryRange (aeronautics)Simple (philosophy)Organic chemistryCatalysisEpistemologyMaterials scienceComposite materialPhilosophyFluorine in Organic ChemistryRadical Photochemical ReactionsChemical Synthesis and Analysis