The 14-3-3σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway
Jia Song, Yachong Liu, Furong Liu, Lu Zhang, Ganxun Li, Chaoyi Yuan, Chengpeng Yu, Xun Lu, Qiumeng Liu, Xiaoping Chen, Huifang Liang, Zeyang Ding, Bixiang Zhang
Abstract
Our results indicate that 14-3-3σ plays a pivotal role in the anoikis resistance and metastasis of HCC cells, presumably by inhibiting EGFR degradation and regulating the activation of the EGFR-dependent ERK1/2 pathway. To our best knowledge, this is the first report of the role of 14-3-3σ in the anoikis resistance of HCC cells, offering new research directions for the treatment of metastatic cancer by targeting 14-3-3σ.
Topics & Concepts
AnoikisCancer researchDegradation (telecommunications)Signal transductionChemistryCell biologyBiologyApoptosisBiochemistryComputer scienceProgrammed cell deathTelecommunications14-3-3 protein interactionsMicrobial Natural Products and BiosynthesisATP Synthase and ATPases Research