The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma
Kang Li, Xianhai Zeng, Peng Liu, Xiaoxia Zeng, Jie Lv, Shuqi Qiu, Peng Zhang
Abstract
Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis.
Topics & Concepts
Head and neck squamous-cell carcinomaInflammationHead and neckBasal cellMedicineOncologyCarcinomaInternal medicineHead and neck cancerPathologyCancerSurgeryImmune cells in cancerNF-κB Signaling PathwaysCancer-related molecular mechanisms research