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Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease

Ryosuke Saigusa, Payel Roy, Antoine Freuchet, Rishab Gulati, Yanal Ghosheh, Sujit Silas Armstrong Suthahar, Christopher P. Durant, David B. Hanna, William B. Kiosses, Marco Orecchioni, Lai Wen, Runpei Wu, Mark H. Kuniholm, Alan Landay, Kathryn Anastos, Phyllis C. Tien, Stephen J. Gange, Seble Kassaye, Jenifer Vallejo, Catherine C. Hedrick, William W. Kwok, Alessandro Sette, Howard N. Hodis, Robert C. Kaplan, Klaus Ley

2022Nature Cardiovascular Research48 citationsDOIOpen Access PDF

Topics & Concepts

Apolipoprotein BT cellBiologyMajor histocompatibility complexEpitopeImmunologyAntigenMolecular biologyImmune systemEndocrinologyCholesterolAtherosclerosis and Cardiovascular DiseasesSingle-cell and spatial transcriptomicsT-cell and B-cell Immunology
Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease | Litcius