The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli
Yasuhiro Kyono, Lori Ellezian, YueYue Hu, Kanella Eliadis, Junlone Moy, Elizabeth B. Hirsch, Michael J. Federle, Stephanie A. Flowers
Abstract
AAP medication is a cornerstone in the treatment of serious psychiatric disease. The AAPs are known to exhibit antimicrobial activity; therefore, a potential unintended risk of long-term AAP use may be the emergence of AMR, although such risk has received little attention.
Topics & Concepts
BiologyQuetiapineAntibiotic resistanceGeneticsOperonMicrobiologyMutantGeneAntibioticsMedicineSchizophrenia (object-oriented programming)PsychiatryTryptophan and brain disordersPhenothiazines and Benzothiazines Synthesis and ActivitiesSchizophrenia research and treatment