Impaired 25-hydroxylation of vitamin D in liver injury suppresses intestinal Paneth cell defensins, leading to gut dysbiosis and liver fibrogenesis
Pengfei Wu, Ruofei Zhang, Mei Luo, Tianci Zhang, Lisha Pan, Siya Xu, Liwei Pan, Feng Ren, Cheng Ji, Richard Hu, Mazen Noureddin, Stephen J. Pandol, Yuan‐Ping Han
2020American Journal of Physiology-Gastrointestinal and Liver Physiology34 citationsDOIOpen Access PDF
Abstract
Vitamin D deficiency is coprevalent with various liver diseases, indicating the role of vitamin D in maintaining liver homeostasis. In this study, we observed that the hepatic 25-hydroxylation of VD is critical for intestinal innate immunity through VD signaling in the small intestine for maintaining Paneth cell functions. Conversely, failure of biogenesis of VD in the liver impairs intestinal immunity, leading to gut dysbiosis and endotoxemia, which promotes liver fibrogenesis.
Topics & Concepts
Paneth cellDysbiosisHydroxylationInternal medicineLiver injuryVitaminMedicineChemistryGastroenterologyGut floraImmunologyBiochemistrySmall intestineEnzymeVitamin D Research StudiesDigestive system and related healthInfant Nutrition and Health