Electrochemically Promoted [3 + 2] Annulation of Imidazo[1,2-<i>a</i>]pyridine with Alkynes
Mengqi Ping, Ming‐Zhong Guo, Rui-Tao Li, Zichen Wang, Cheng Ma, Li‐Rong Wen, Shao‐Fei Ni, Weisi Guo, Ming Li, Lin‐Bao Zhang
Abstract
]pyridines with alkynes using traceless electrons as green reagents has been developed, leading to the synthesis of a large class of polycyclic heteroaromatics in good yields with a broad substrate scope under mild and green conditions. The scaled-up experiment, follow-up procedures, and potential biological applications show the practicability and feasibility of the electrochemical method.
Topics & Concepts
AnnulationChemistryReagentPyridineCombinatorial chemistryElectrochemistryScope (computer science)Substrate (aquarium)Organic chemistryCatalysisPhysical chemistryElectrodeComputer scienceOceanographyProgramming languageGeologyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques