Synthesis and Antinociceptive Activity of Substituted 5-(Het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones
D. V. Lipin, E. I. Denisova, I. О. Devyatkin, Elizaveta Okoneshnikova, D. A. Shipilovskikh, Р. Р. Махмудов, Н. М. Игидов, Sergei A. Shipilovskikh
Abstract
The method was proposed for the synthesis of new substituted 5-(het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones by intramolecular cyclization of 2-[2-(4-methylbenzoyl)hydrazono]-4-oxobut-2-enoic acids in the presence of propionic anhydride. The antinociceptive activity of the obtained compounds was studied.
Topics & Concepts
ChemistryFuranArylIntramolecular forceMedicinal chemistryStereochemistryOrganic chemistryAlkylChemical synthesis and pharmacological studiesOrganic Chemistry Synthesis MethodsSynthesis and Biological Evaluation