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RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease

Jeffrey Schmeckpeper, Kyungsoo Kim, Sharon A. George, Daniel J. Blackwell, Jaclyn A. Brennan, Igor R. Efimov, Björn C. Knollmann

2023Journal of Molecular and Cellular Cardiology23 citationsDOIOpen Access PDF

Topics & Concepts

DantroleneMedicineCardiologyPathologicalCardiac function curveRyanodine receptor 2Internal medicineDiseaseHeart failureRyanodine receptorCalciumCardiac electrophysiology and arrhythmiasCardiac Ischemia and ReperfusionIon channel regulation and function
RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease | Litcius