Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
M.J. Nagesh Khadri, Ramith Ramu, N. Akshaya Simha, Shaukath Ara Khanum
Topics & Concepts
PyrazoleChemistryThiopheneSubstituentDocking (animal)StereochemistryCyclooxygenaseAnti-inflammatoryAnalgesicPharmacophorePharmacologyEnzymeBiochemistryOrganic chemistryMedicineNursingSynthesis and biological activitySynthesis of heterocyclic compoundsInflammatory mediators and NSAID effects