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Reassessment of Historical Clinical Trials Supports the Effectiveness of Phage Therapy

Luigi Marongiu, Markus Burkard, Ulrich M. Lauer, Ludwig E. Hoelzle, Sascha Venturelli

2022Clinical Microbiology Reviews62 citationsDOIOpen Access PDF

Abstract

value = 0.0009). The results suggest phage therapy was surprisingly less effective than standard treatments in resolving bacterial infections. However, the results were affected by the small sample set size. This work also contextualizes the development of phage therapy in the early 20th century and highlights the expansion of phage applications in the last few years. In conclusion, the current review shows phage therapy is no longer an underestimated tool in the treatment of bacterial infections.

Topics & Concepts

Clinical trialPhage therapyMedicineAntibioticsOdds ratioAntibiotic therapyInternal medicineConfidence intervalIntensive care medicineBacteriophageMicrobiologyBiologyEscherichia coliBiochemistryGeneBacteriophages and microbial interactionsMicrobial infections and disease researchPlant Virus Research Studies