The alleviating effect of ellagic acid on DSS-induced colitis <i>via</i> regulating gut microbiomes and gene expression of colonic epithelial cells
Xiaoqing Li, Xiaoqing Li, Lu Xu, Xinan Peng, Huiting Zhang, Meng Kang, Yiqi Jiang, Haibo Shi, Haiyan Chen, Chao Zhao, Yigang Yu, Ruiting Ma, Xueli Li, Xueli Li, Yong Cao
Abstract
and Muribaculaceae, while decreasing the proportion of Firmicutes. The Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2 (PICRUSt2) revealed that the metabolic function of the gut microbiota was also changed. Furthermore, mouse colon transcriptome analysis showed that the tight junction and peroxisome proliferator-activated receptor (PPAR) signaling pathways were activated and the expressions of related genes were upregulated after EA intervention. These results showed that EA could remodel the gut bacterial composition, change the intestinal epithelial cell gene expressions in mice, and consequently improve the colonic inflammatory symptoms.