C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function
Ahmed Attia Ahmed Abdelmoaty, Ping Zhang, Wen Lin, Yingjuan Fan, Shengnan Ye, Jianhua Xu
Topics & Concepts
Hsp90CurcuminProtein kinase BMAPK/ERK pathwayPI3K/AKT/mTOR pathwayApoptosisCancer researchChemistryIn vitroHeat shock proteinGrowth inhibitionBiologyPharmacologyMolecular biologySignal transductionBiochemistryGeneHeat shock proteins researchCurcumin's Biomedical ApplicationsComputational Drug Discovery Methods