Wnt Signaling Pathways: A Role in Pain Processing
Yiting Tang, Yupeng Chen, Rui Liu, Weidong Li, Baojin Hua, Yanju Bao
Abstract
The wingless-related integration site (Wnt) signaling pathway plays an essential role in embryonic development and nervous system regulation. It is critically involved in multiple types of neuropathic pain (NP), such as HIV-related NP, cancer pain, diabetic neuralgia, multiple sclerosis-related NP, endometriosis pain, and other painful diseases. Wnt signaling is also implicated in the pain induced by sciatic nerve compression injury and selective spinal nerve ligation. Thus, the Wnt signaling pathway may be a potential therapeutic target for NP.
Topics & Concepts
Wnt signaling pathwaySignal transductionPain medicineNeuroscienceComputational biologyBiologyMedicineCell biologyPathologyAnesthesiologyPain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyHereditary Neurological Disorders